Key result
Mobility impairment during AMI hospitalization is linked to ~80% higher 12-month mortality.
Why the study?
Does baseline mobility impairment predict one-year mortality and rehospitalization in adults surviving an acute myocardial infarction?
Cohort (n=1,093)
No
Does baseline mobility impairment predict one-year mortality and rehospitalization in adults surviving an acute myocardial infarction?
Relative Risk: 1.8 (95% CI 1.01–3.18)
p-value: p=0.045
Baseline mobility impairment assessed during index hospitalization for acute myocardial infarction is independently associated with increased one-year mortality and rehospitalization, suggesting patient-reported outcomes can complement traditional clinical risk stratification.
Mobility impairment during AMI hospitalization may refine 1-year risk stratification; leaves open whether targeted interventions improve outcomes.
Background Acute myocardial infarction (AMI) remains a leading cause of death worldwide and in Colombia. Beyond survival, AMI can markedly impair health-related quality of life (HRQoL), yet the prognostic value of HRQoL measured during the index hospitalization remains insufficiently explored, particularly in middle-income countries. Methods We conducted a prospective cohort study of 1,093 adults with type 1 myocardial infarction admitted to a tertiary referral center in Colombia between 2023 and 2025. HRQoL was assessed within 24 hours of admission using the EuroQol 5-Dimension 3-Level (EQ-5D-3L) instrument and the EuroQol Visual Analogue Scale (EQ-VAS). Multivariable Poisson regression with robust variance was used to estimate adjusted risk ratios (RRs) for one-year mortality and rehospitalization. Results At 12 months, all-cause mortality was 4.3% and rehospitalization was 2.6%. Impairment in the mobility domain was independently associated with higher risks of mortality (RR = 1.80; p = 0.045) and rehospitalization (RR = 2.22; p = 0.031). Percutaneous coronary intervention (RR = 0.28; p < 0.001) and male sex (RR = 0.54; p = 0.034) were associated with lower mortality risk. Conclusion Baseline HRQoL assessed during hospitalization for AMI was associated with one-year mortality and rehospitalization. Mobility limitations identified patients at higher risk and may complement conventional clinical risk stratification.
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Pérez et al. (2026) conducted a cohort in Acute myocardial infarction (n=1,093). Mobility impairment (EQ-5D-3L) vs. No mobility problems was evaluated on 12-month all-cause mortality (RR 1.80, 95% CI 1.01-3.18, p=0.045). Impairment in the mobility domain assessed during hospitalization for acute myocardial infarction was associated with a higher risk of 12-month all-cause mortality (RR 1.80).
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