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July 10, 2026npj VaccinesOpen Access

Post-exposure vaccination with an adjuvanted protein subunit vaccine, but not BCG, protects mice and guinea pigs against M. tuberculosis

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Authors

JWJoshua S. WoodworthStatens Serum InstitutCAClaus AagaardStatens Serum InstitutFSFrancisco J. SalgueroDefence Science and Technology Laboratory

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Implication

Randomized trial evaluates H107/CAF01 vaccine efficacy in post-exposure models, highlighting its potential over BCG.

Key Points

  • This research aims to assess the efficacy of H107/CAF®01 in protecting against M. tuberculosis in previously exposed animal models.
  • Introduced murine reinfection and guinea pig reactivation models for testing vaccine efficacy.
  • Compared the adjuvanted protein subunit vaccine H107/CAF®01 against BCG in these models.
  • Evaluated immune responses and bacterial burden post-vaccination.
  • H107/CAF®01 demonstrated significant protection reducing bacterial burden and tissue pathology.
  • BCG did not provide significant protection in post-Mtb-exposed settings.
  • H107/CAF®01 induced strong Th17 responses indicating robust immune protection.

Cite This Study

Woodworth et al. (2026) studied this question.

synapsesocial.com/papers/6a508b536eeac72a4379fffdhttps://doi.org/10.1038/s41541-026-01509-6
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