What question did this study set out to answer?

This research aims to develop a novel paper-based device to directly detect small-molecule biomarkers in whole blood.

Direct Whole-Blood Multiplexing of Small Molecules via a Micelle-Enhanced Chemiluminescent Paper Sensor with Mesoporous Silica Membrane

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Randomized trial demonstrates effective detection of biomarkers in whole blood, suggesting a new on-site diagnostic tool.

This research aims to develop a novel paper-based device to directly detect small-molecule biomarkers in whole blood.
Integration of a core-shell mesoporous silica membrane to separate red blood cells.
Utilization of AIE-active dyes enclosed in micelles for enhanced luminescent detection.
Evaluation of glucose, uric acid, and xanthine in whole blood without separation steps.
Achieved simultaneous detection of glucose, uric acid, and xanthine with low detection limits.
Reported excellent signal-to-noise ratio, ensuring reliable results within 45 min.
Demonstrated high reproducibility across multiple tests.

Wang et al. (2026) studied this question.

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