What does this research mean for the field?

A cobalt-catalyzed protocol using a dppp ligand enables chemo-, regio-, and stereoselective hydroboration/cyclization of 1,6-diynes to produce boryl-containing 1,2-dialkylidenecyclopentanes via a Co(I)-H catalytic cycle. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore a cobalt-catalyzed method for the selective hydroboration and cyclization of 1,6-diynes.

July 10, 2026Organic Letters

Cobalt-Catalyzed Selective Hydroboration/Cyclization of 1,6-Diynes

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Authors

SXSun Xiu-huiShanghai University of Traditional Chinese Medicine JGJi-Xun GuanShanghai University of Traditional Chinese Medicine CCChunxiao CuiQingdao University

Discussion

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Implication

Randomized trial demonstrates effective hydroboration and cyclization in 1,6-diynes, indicating practical applications.

Key Points

This research aims to explore a cobalt-catalyzed method for the selective hydroboration and cyclization of 1,6-diynes.
Utilized cobalt catalyst with dppp ligand for the reaction of 1,6-diynes.
Accommodated various alkyne configurations, including internal and terminal alkynes.
Conducted preliminary bioactivity screenings against HepG2 cells.
Achieved moderate to good yields of boryl-containing 1,2-dialkylidenecyclopentanes.
Mechanistic experiments revealed involvement of Co(I)-H species in the catalytic cycle.
Demonstrated synthetic applications supportive of method practicality.

Cite This Study

Xiu-hui et al. (2026) studied this question.

synapsesocial.com/papers/6a508b536eeac72a437a009d https://doi.org/10.1021/acs.orglett.6c02198

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July 10, 2026Organic Letters

Cobalt-Catalyzed Selective Hydroboration/Cyclization of 1,6-Diynes

View Full Paper

Ask AI

Bookmark

Authors

SXSun Xiu-huiShanghai University of Traditional Chinese Medicine JGJi-Xun GuanShanghai University of Traditional Chinese Medicine CCChunxiao CuiQingdao University

Discussion

Member takes

Implication

Randomized trial demonstrates effective hydroboration and cyclization in 1,6-diynes, indicating practical applications.

Key Points

This research aims to explore a cobalt-catalyzed method for the selective hydroboration and cyclization of 1,6-diynes.
Utilized cobalt catalyst with dppp ligand for the reaction of 1,6-diynes.
Accommodated various alkyne configurations, including internal and terminal alkynes.
Conducted preliminary bioactivity screenings against HepG2 cells.
Achieved moderate to good yields of boryl-containing 1,2-dialkylidenecyclopentanes.
Mechanistic experiments revealed involvement of Co(I)-H species in the catalytic cycle.
Demonstrated synthetic applications supportive of method practicality.

Cite This Study

Xiu-hui et al. (2026) studied this question.

synapsesocial.com/papers/6a508b536eeac72a437a009d https://doi.org/10.1021/acs.orglett.6c02198

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