The Modulatory Role of Uridine on Nutrition-Related Molecules in a Rat Model of Polycystic Ovary Syndrome

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This research aims to explore the effects of uridine on key peptides related to energy balance in a rat model of polycystic ovary syndrome (PCOS).
Used 35 female Sprague-Dawley rats, aged 8-10 weeks, to induce PCOS using dehydroepiandrosterone injections over 21 days.
Administered uridine intraperitoneally at doses of 250 or 500 mg/kg for 5 days, equivalent to one estrous cycle.
Measured serum levels of orexin-A, nesfatin-1, and leptin using ELISA and analyzed data with one-way ANOVA and Holm-Sidak test.
Uridine treatment significantly affected serum levels of leptin, nesfatin-1, and orexin-A in the PCOS model.
Results suggest potential therapeutic implications for managing hormonal and metabolic imbalances in PCOS.

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Investigates uridine effects on metabolic peptides in rats with polycystic ovary syndrome, suggesting therapeutic potential.

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Üstünbaş et al. (2026) studied this question.

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