Bioactivity Research in Ganoderma lucidum: A Scientometric Analysis of Global Trends, Translational Gaps, and Emerging Research Frontiers

Ganoderma lucidum (Lingzhi or Reishi) is among the most extensively studied medicinal mushrooms globally, owing to its diverse bioactive compounds and broad pharmacological properties. A scientometric analysis using the Scopus database was conducted to investigate global research trends on the bioactivity of G. lucidum. Bibliometric indicators, collaboration networks, keyword co-occurrence, thematic evolution, conceptual structure mapping, and life cycle modeling were assessed using Bibliometrix/Biblioshiny and VOSviewer version 1.6.20. A total of 2877 publications were included in the analysis. Scientific output increased markedly after 2010, peaking in 2025, indicating sustained growth in the field. China was identified as the leading contributor in terms of publication volume, influential authors, and prominent institutions, while international collaboration networks showed expanding global participation. Keyword and thematic analyses demonstrated a shift from early research focused on bioactivity screening, polysaccharides, and cultivation to mechanistic and translational investigations involving apoptosis, oxidative stress, immunomodulation, metabolomics, gut microbiota, network pharmacology, and disease-specific applications. Life cycle analysis suggested that the field is still in a rapid growth phase and has not yet reached saturation. Research on G. lucidum has evolved into a mature and highly interdisciplinary field, characterized by increasing scientific productivity, expanding international collaboration, and a growing emphasis on mechanistic and translational studies.