What question did this study set out to answer?

This review aims to assess the effectiveness of resveratrol as an adjunctive therapy in periodontal disease through systematic analysis of existing studies.

July 10, 2026NutrientsOpen Access

Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis

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Authors

SSSuzanne Ying‐Shan SuTaipei Tzu Chi Hospital ITI‐Shiang TzengTaipei Tzu Chi Hospital THTing-Hsin HuangKaohsiung Chang Gung Memorial Hospital

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Implication

Systematic review evaluates resveratrol's effects on periodontal disease, suggesting modest improvements in non-smoking individuals.

Key Points

This review aims to assess the effectiveness of resveratrol as an adjunctive therapy in periodontal disease through systematic analysis of existing studies.
Electronic searches conducted on databases from 2000 to 2025.
Included in vitro, in vivo, and randomized clinical trials on resveratrol for periodontal therapy.
Data extraction and meta-analysis followed PRISMA guidelines.
Inhibitory effect of resveratrol on IL-1β, IL-6, TNF-α, and IL-8 in vitro with low to moderate heterogeneity.
In animal studies, resveratrol significantly reduced alveolar bone loss and IL-1β protein levels.
In human trials, resveratrol improved probing pocket depth and clinical attachment compared to root planing alone.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a508c766eeac72a437a07ac https://doi.org/10.3390/nu18132212

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Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis

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Key Points

Cite This Study

Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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