Key result
Postoperative day-one troponin T independently links to ~156% higher odds of MODS.
Why the study?
Multiple organ dysfunction syndrome (MODS) is a serious complication and leading cause of death following heart valve surgery, but the predictive capacity of perioperative parameters including Troponin T levels needed assessment.
Does perioperative Troponin T measurement predict postoperative multiple organ dysfunction syndrome and 30-day mortality in patients undergoing heart valve surgery?
Cohort (n=739)
No
Does perioperative Troponin T measurement predict postoperative multiple organ dysfunction syndrome and 30-day mortality in patients undergoing heart valve surgery?
Troponin T levels measured on the first postoperative day independently predict multiple organ dysfunction syndrome and 30-day mortality in patients undergoing heart valve surgery, offering prognostic value beyond standard risk calculators like EuroSCORE II.
Postoperative troponin T may refine MODS risk stratification after valve surgery; leaves open whether routine use improves outcomes in prospective studies.
Background: Multiple organ dysfunction syndrome (MODS) is a serious complication and a leading cause of death in patients undergoing heart valve surgery. The main aim of the present study was to assess the predictive capacity of selected perioperative parameters, including Troponin T levels, to predict the occurrence of postoperative MODS and 30-day mortality in patients undergoing heart valve surgery. Methods: This prospective study included a group of patients with hemodynamically severe symptomatic valvular heart disease who underwent valve surgery. The primary endpoint was postoperative multiple organ dysfunction syndrome (MODS), defined as the dysfunction of at least two organs/systems, including cardiogenic shock, perioperative stroke, respiratory failure requiring prolonged mechanical ventilation, and/or postoperative acute kidney injury requiring renal replacement therapy. The secondary endpoint was death during the 30-day follow-up. Logistic regression was used to assess the relationships between the variables. Results: In total, 739 patients undergoing valvular heart surgery were included in this study. The primary end point was observed in 45 patients. Preoperative hemoglobin level (p = 0.01), red cell distribution width (RDW) (p = 0.001) and troponin T level measured on the first day after surgery (TnT II) (p < 0.001) were independent predictors of the primary endpoint. EuroSCORE II (p = 0.002) and TnT II (p < 0.001) were independent predictors of 30-day mortality. Conclusions: MODS is a clinical condition that is associated with a high risk of death. Troponin T levels measured within the first 24 h postoperatively may be useful in predicting postoperative MODS and 30-day mortality in patients undergoing heart valve surgery as a complement to commonly used risk calculators.
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Duchnowski et al. (2026) conducted a cohort in Hemodynamically severe symptomatic valvular heart disease (n=739). Troponin T level measured on postoperative day 1 (TnT II) was evaluated on Postoperative multiple organ dysfunction syndrome (MODS) (OR 2.557, 95% CI 1.813-3.605, p=<0.001). Troponin T levels measured on the first postoperative day independently predicted the occurrence of postoperative multiple organ dysfunction syndrome (OR 2.557).
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