Retinal Pigment Epithelial Detachment Following Topical Travoprost Therapy

Case RepoRtincrease vascular permeability through prostaglandin-mediated vasodilation, offering a plausible explanation for posterior segment involvement. 8In addition, prostaglandins may impair retinal pigment epithelial tight junctions and disrupt the outer blood-retinal barrier, a mechanism similar to that implicated in prostaglandin-associated CME. 9 Reports of RPED associated with prostaglandin analog therapy are limited, which may partly reflect underrecognition, as mild cases can be asymptomatic and identified only through routine optical coherence tomography (OCT).Considering the long-term use of travoprost, particularly in older patients who may have subtle chorioretinal susceptibility, even infrequent adverse effects can carry significant visual consequences. 10,11his case series contributes additional evidence to the existing literature by documenting RPED occurring during topical travoprost therapy.