Restrictive Vs. Standard Fluid Management in Mechanically Ventilated Children Admitted to PICU: A Pilot Randomized Controlled Trial

View Full Paper

Ask AI

Bookmark

Share

Key Points

This pilot trial aims to evaluate the feasibility of a randomized controlled trial comparing restrictive versus standard IV fluid management in mechanically ventilated children.
Pilot, parallel-arm, open-label randomized controlled trial conducted across PICUs in Australia and Switzerland.
Patients aged under 18 expected to be mechanically ventilated for over 6 hours were randomly assigned to either restrictive IV fluid or usual care for 48 hours.
Recruitment involved 158 consenting parents out of 1224 eligible patients during 2021-2023.
Only 0% of patients in the restrictive strategy achieved a negative fluid balance greater than 10% body weight within 24 hours, compared to 6% in the usual care arm.
Median fluid balance at 48 hours postrandomization was higher in the restrictive strategy (11.1 mL/kg, IQR -13.7, 40.2) compared to usual care (8.6 mL/kg, IQR -18.7, 38.8).
Median survival free of PICU was 25.0 days (restrictive) vs. 24.0 days (usual care).

We only have this paper's title and publication details.

Pilot trial assesses fluid management strategies in pediatric intensive care with implications for future studies.

No takes yet. Share an insight, caveat, or question.

Raman et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share