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July 10, 2026ReceptorsOpen Access

Protective and Detrimental Roles of NLRP6 in Infection and Cancer

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Authors

TYTakayoshi YamauchiVJVaibhav JainSGSimon G. Gregory

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Overview

This review outlines how NLRP6 influences infection and cancer outcomes, emphasizing its dual role in different tissues.

Key Points

  • The review aims to explore the complex roles of NLRP6 in infection and cancer, highlighting its dual protective and detrimental effects.
  • Summarizes findings from recent studies on NLRP6's functions across various tissues.
  • Examines the implications of NLRP6 in both protective and pathological contexts.
  • Discusses the gut–liver axis and the use of knockout models to understand NLRP6's impact.
  • NLRP6 is protective in the intestine, aiding in antiviral defense and maintaining barrier integrity.
  • In systemic infections, NLRP6 can promote pathology by inhibiting NF-κB signaling and inducing lymphocyte death.
  • Tissue-specific knockout studies reveal the significance of the gut–liver axis in NLRP6-related diseases.

Cite This Study

Yamauchi et al. (2026) studied this question.

synapsesocial.com/papers/6a508cc46eeac72a437a09c2https://doi.org/10.3390/receptors5030023
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