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July 10, 2026Journal of Clinical Apheresis

Outcomes in Recurrent Focal Segmental Glomerulosclerosis Post‐Kidney Transplantation Treated With Therapeutic Plasma Exchange: A Retrospective Cohort Study

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Authors

COChimezie OkwuonuMHMuzamil HassanOOOlalekan Ojo

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Overview

Retrospective cohort study shows therapeutic plasma exchange improves remission rates in recurrent FSGS, suggesting early intervention is key.

Key Points

  • The study aims to assess the efficacy of therapeutic plasma exchange in patients with recurrent focal segmental glomerulosclerosis post-kidney transplantation.
  • Retrospective cohort study with 20 patients diagnosed with FSGS before transplantation.
  • Patients underwent therapeutic plasma exchange over a 6-year period, with data on demographics and treatment parameters collected and analyzed using SPSS.
  • Outcomes included remission rates of proteinuria and time to remission, along with complication rates.
  • 15 out of 20 patients (75%) achieved remission of proteinuria after a median of 6 months.
  • Higher odds of remission were linked to receiving more than five TPE sessions (AOR = 1.6; p = 0.02) and lower baseline proteinuria (AOR = 1.9; p = 0.01).
  • The procedure had a 10.7% complication rate, primarily hypocalcemia, and a low mortality rate of 0.6%.

Cite This Study

Okwuonu et al. (2026) studied this question.

synapsesocial.com/papers/6a508da76eeac72a437a1014https://doi.org/10.1002/jca.70156
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Review of plasma exchange and rituximab for prevention of recurrent focal segmental glomerulosclerosis after a prior graft loss2024
  2. 2Efficacy of Low-Density Lipoprotein Apheresis in an Adult Case of Recurrent Focal Segmental Glomerulosclerosis Post-kidney Transplant2026
  3. 3Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study2026 · 5 citations
  4. 4#1315 Management and long-term outcome of recurrent idiopathic FSGS in pediatric renal transplant recipients2024
  5. 5Prophylactic treatment of FSGS recurrence in patients who relapsed on a previous kidney graft2024 · 6 citations