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This review aims to assess the reporting quality and adherence to pre-analytical standards in eccDNA studies related to cancer.

July 10, 2026CancersOpen Access

Assessing Reporting Quality and Pre-Analytical Standards in Extrachromosomal Circular DNA Studies in Cancer: A Systematic Review

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Systematic review evaluates pre-analytical standards and reporting in eccDNA studies, suggesting improvements for transparency.

This review aims to assess the reporting quality and adherence to pre-analytical standards in eccDNA studies related to cancer.
Systematically reviewed 14 eccDNA studies published between 2017 and 2025.
Evaluated studies against 22 checklist items derived from the NCI Biospecimen Collection and Processing Guideline.
Classified reporting of items as 'reported', 'not reported', or 'deviated from NCI guideline', then calculated missing/deviation rates.
Publication of studies was predominantly post-guideline with 13 out of 14 published after 2020.
Significant reporting gaps were found, with 100% missing data on venipuncture site and freeze-thaw cycles.
The extraction method was consistently reported (0% missing), indicating potential areas for improvement.

Tian et al. (2026) studied this question.

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