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July 10, 2026Applied Health Economics and Health PolicyOpen Access

The Cost Effectiveness of Treatment Strategies for Depression in Ethiopia: A Multiple Cohort Markov Model Analysis

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Authors

YBYared Belete BelayMonash UniversityCMCathrine MihalopoulosDeakin UniversityLELidia EngelAustralian Regenerative Medicine Institute

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Implication

Randomized trial evaluates cost-effectiveness of depression treatments in Ethiopia, suggesting psychotherapy is favorable.

Key Points

  • This analysis evaluated the cost-effectiveness of various depression treatment interventions for adults in Ethiopia.
  • Developed a multiple cohort Markov model to simulate health state transitions.
  • Compared three drug interventions, psychotherapy, and combination therapy against a partial null scenario.
  • Employed cost-utility analysis over a 10-year period with 3000 Monte Carlo iterations.
  • Psychotherapy had an ICER of US$1,419 per QALY gained, indicating cost-effectiveness.
  • Combination therapy showed the highest health benefit at 40,755 QALYs with an ICER of US$3,973/QALY.
  • Antidepressants, such as SNRIs, were not cost-effective based on the thresholds established.

Cite This Study

Belay et al. (2026) studied this question.

synapsesocial.com/papers/6a508e5b6eeac72a437a140chttps://doi.org/10.1007/s40258-026-01055-1
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