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This study aims to develop an efficient method for the extraction of bioactive compounds from licorice root meal.

July 10, 2026MoleculesOpen Access

Selective Extraction of Lipophilic Bioactive Compounds from Industrial Root Meal of Glycyrrhiza glabra L.

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Randomized trial develops an efficient method to extract bioactive compounds from licorice root meal, indicating potential for better resource use.

This study aims to develop an efficient method for the extraction of bioactive compounds from licorice root meal.
Centrifugation-based sequential ethanol extraction followed by selective fractionation using petroleum ether–ethyl acetate.
Chromatographic purification of extracted compounds.
Yield assessment of bioactive compounds such as glabridin and triterpenoids.
Isolated glabridin with a purity of 87.9% and yield of 0.17%.
Achieved a lipid fraction containing β-sitosterol and stigmasterol at 1.1%.
Extraction yield with ethanol was 7.1%, optimizing levels of glabridin and total flavonoids.

Sanoev et al. (2026) studied this question.

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Randomized trial develops an efficient method to extract bioactive compounds from licorice root meal, indicating potential for better resource use.