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This research aims to evaluate the prognostic role of PD-L1 expression in high-grade serous ovarian carcinoma regarding recurrence-free survival.

July 10, 2026BMC CancerOpen Access

Recurrence-free survival is prolonged in high-grade serous ovarian cancer with high PD-L1 expression

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Retrospective study finds high PD-L1 density improves recurrence-free survival in HGSOC, suggesting prognostic potential.

This research aims to evaluate the prognostic role of PD-L1 expression in high-grade serous ovarian carcinoma regarding recurrence-free survival.
Included 47 patients with high-grade serous ovarian cancer and matched recurrent tumor samples.
Conducted immunohistochemistry on tissue microarrays and quantified PD-1 and PD-L1 immune-cell densities.
Analyzed correlations using Kaplan-Meier and Cox regression for survival associations.
High primary PD-L1 density linked to longer recurrence-free survival (RFS) compared to low-density (log-rank p = 0.032).
No significant difference in RFS based on PD-1 immune-cell density (p = 0.18).
Neither PD-L1 nor PD-1 densities significantly associated with overall survival in the cohort.

Lalos et al. (2026) studied this question.

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