MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Mild hypertension (n=17354). Intervention: Active treatment (bendrofluazide or propranolol) vs. Placebo. Primary outcome: Stroke (p=<0.01).

doi:10.1136/bmj.291.6488.97

July 13, 1985BMJOpen Access

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

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Study Design

Type

RCT (n=17,354)

Blinding

Single-blind

Randomization

Randomly allocated

Multicenter

Yes

PICO

P

Population

17,354 men and women aged 35-64 years with mild hypertension, followed for a total of 85,572 patient-years.

I

Intervention / Comparator

Active treatment (bendrofluazide or propranolol) vs Placebo

O

Primary Outcome

Stroke, p=<0.01

Main Result

Absolute Event Rate: 1.4% vs 2.6%

p-value: p=<0.01

Limitations

Post hoc analyses of subgroup results require very cautious interpretation.

Abstract

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Discussion

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Cite This Study

A 1985 study conducted an RCT in Mild hypertension (n=17,354). Active treatment (bendrofluazide or propranolol) vs. Placebo was evaluated on Stroke (p=<0.01).

synapsesocial.com/papers/6a510487a45face081a15701 https://doi.org/10.1136/bmj.291.6488.97

View Full Paper

Ask AI

Bookmark

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MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Study Design

PICO

Main Result

Limitations

Abstract

Discussion

Cite This Study

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Study Design

PICO

Main Result

Limitations

Abstract

Discussion

Cite This Study

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