Key result
The Modified Frailty Index (mFI) yielded the best predictive power for both all-cause mortality and cardiac resynchronization therapy response with an AUC of 0.701 compared to ScREEN and EAARN scores.
Why the study?
Does the Modified Frailty Index predict CRT response and all-cause mortality in patients with heart failure compared to conventional scores?
Observational (n=93)
No
Does the Modified Frailty Index predict CRT response and all-cause mortality in patients with heart failure compared to conventional scores?
Effect estimate: AUC 0.701
The Modified Frailty Index offers modest predictive value for CRT response and mortality, comparable to conventional scores, but provides additional benefit in predicting short-term hospital outcomes.
OBJECTIVE: ), LVEF ≥25%, ECG (QRS duration ≥150 ms) and NYHA class ≤III) score for predicting cardiac resynchronization therapy (CRT) response and all-cause mortality. METHODS: In this prospective, non-randomized, single-center, observational study we enrolled 93 patients receiving CRT from August 2016 to August 2019. Pre-implant scores were calculated, and patients were followed for six months. Performance of each score for prediction of CRT response (defined as ≥15% reduction in left ventricular end-systolic volume [LVESV]) and all-cause mortality was compared. RESULTS: Optimal CRT response was seen in seventy patients with nine deaths. All the three scores exhibited modest performance for prediction of CRT response and all-cause mortality with AUC ranging from 0.608 to 0.701. mFI has an additional benefit for prediction of prolonged post-procedure stay and 30-day rehospitalization events. CONCLUSION: mFI, ScREEN and EAARN score can be used reliably for predicting all-cause mortality and response to CRT.
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Raj et al. (2021) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=93). Modified Frailty Index (mFI) vs. ScREEN and EAARN scores was evaluated on Prediction of all-cause mortality and cardiac resynchronization therapy (CRT) response (AUC 0.701). The Modified Frailty Index (mFI) yielded the best predictive power for both all-cause mortality and cardiac resynchronization therapy response with an AUC of 0.701 compared to ScREEN and EAARN scores.
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