Key result
The role of platelets in chronic kidney disease regarding excessive clotting, bleeding, and inflammation remains undefined, highlighting the need for further mechanistic studies.
Why the study?
Platelet-dependent mechanisms for clotting, bleeding, and inflammation in CKD remain undefined, and descriptions of platelet functional changes during CKD have provided confusing interpretations.
This review emphasizes the need for further experimental approaches to understand platelet dysfunction, thrombosis, and bleeding in chronic kidney disease.
Confusing platelet data in CKD leave mechanisms undefined; leaves open whether new experimental models can clarify therapeutic targets.
Platelet-dependent mechanisms for excessive clotting and bleeding in CKD remain undefined. Moreover, platelets' contribution to inflammation, and specifically to CKD, are equally elusive. To date, descriptions of changes in the functional properties of circulating platelets during CKD have provided confusing interpretations. Experimental approaches that can advance our understanding of platelet dysfunction in CKD are needed, and studies that provide mechanistic insights into the dynamic relationships between thrombosis, bleeding, and inflammation associated with CKD will be essential to improve clinical management and outcomes for this vulnerable population. This article summarizes existing literature characterizing platelets in CKD and identifies areas that need further investigation.
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Jain et al. (2021) conducted a review in Chronic Kidney Disease. Platelets was evaluated. The role of platelets in chronic kidney disease regarding excessive clotting, bleeding, and inflammation remains undefined, highlighting the need for further mechanistic studies.
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