Key result
The ketogenic diet may improve cardiovascular health via enhanced myocardial ketone body utilization, though hyperlipidemia, poor adherence, and unknown long-term effects remain significant concerns.
Why the study?
The ketogenic diet may improve cardiac energetics, but adverse effects like hyperlipidemia and poor adherence raise questions regarding its broader cardiovascular applicability.
Does the ketogenic diet improve cardiovascular health through altered myocardial ketone body utilization?
Does the ketogenic diet improve cardiovascular health through altered myocardial ketone body utilization?
While the ketogenic diet may offer cardiovascular benefits through improved cardiac energetics, its broader applicability is challenged by adverse effects such as hyperlipidemia and poor long-term adherence.
KD may confer CV benefits via hyperketonemia in T2D/obesity; leaves open confirmation by RCTs before clinical use.
The ketogenic diet (KD) entails a high intake of fat, moderate intake of protein, and a very limited intake of carbohydrates. Ketogenic dieting has been proposed as an effective intervention for type 2 diabetes and obesity since glycemic control is improved and sustained weight loss can be achieved. Interestingly, hyperketonemia is also associated with beneficial cardiovascular effects, possibly caused by improved cardiac energetics and reduced oxygen use. Therefore, the KD has the potential to both treat and prevent cardiovascular disease. However, the KD has some adverse effects that could counteract the beneficial cardiovascular properties. Of these, hyperlipidemia with elevation of triglycerides and LDL cholesterol levels are the most important. In addition, poor diet adherence and lack of knowledge regarding long-term effects may also reduce the broader applicability of the KD. The objective of this narrative review is to provide insights into the KD and its effects on myocardial ketone body utilization and, consequently, cardiovascular health.
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Luong et al. (2022) conducted a review in Cardiovascular disease. Ketogenic diet was evaluated. The ketogenic diet may improve cardiovascular health via enhanced myocardial ketone body utilization, though hyperlipidemia, poor adherence, and unknown long-term effects remain significant concerns.
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