What question did this study set out to answer?

The study aims to assess the efficacy and safety of apixaban for treating acute deep venous thrombosis in cancer patients compared to low-molecular weight heparin.

November 5, 2020Vascular

Efficacy and safety of apixaban in patients with active malignancy and acute deep venous thrombosis

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Authors

MMMostafa El MokademBeni-Suef University AHAhmed M. HassanChandigarh University AAAbdulaziz Z AlgabyBeni-Suef University

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Implication

Randomized trial evaluates apixaban efficacy and safety in patients with malignancy and deep venous thrombosis, suggesting it may be comparable to heparin.

Key Points

The study aims to assess the efficacy and safety of apixaban for treating acute deep venous thrombosis in cancer patients compared to low-molecular weight heparin.
138 patients with acute deep venous thrombosis and active malignancy were randomized in a 1:1 ratio.
100 patients were treated with either oral apixaban or subcutaneous low-molecular weight heparin (enoxaparin).
Follow-up lasted for six months, focusing on major bleeding and other related outcomes.
No significant differences in major bleeding or secondary endpoints between apixaban and heparin groups.
No mortality cases were linked to massive pulmonary embolism in either treatment group.
84 patients had metastatic cancer, with colorectal cancer being the most common diagnosis (42%).

Cite This Study

Mokadem et al. (2020) studied this question.

synapsesocial.com/papers/6a51a1c1f15e5558024dba03 https://doi.org/10.1177/1708538120971148

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Implication

Randomized trial evaluates apixaban efficacy and safety in patients with malignancy and deep venous thrombosis, suggesting it may be comparable to heparin.

Efficacy and safety of apixaban in patients with active malignancy and acute deep venous thrombosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy and safety of apixaban in patients with active malignancy and acute deep venous thrombosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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