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July 11, 2026The International Journal of Spine SurgeryOpen Access

An Algorithmic Approach Including Local Antibiotic Delivery for Spine Infection Treatment: Outcomes at 1 Institution

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Authors

MDMellissa DelcontASAnna SaterJLJonathan Layne

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Overview

Retrospective analysis demonstrates effective infection resolution with local antibiotic beads in spine infections, suggesting tailored treatment strategies.

Key Points

  • This research aims to evaluate the effectiveness of an algorithmic approach for treating spine infections using local antibiotic delivery.
  • Retrospective analysis of 119 surgically managed spine infection cases from 2016 to 2020.
  • Evaluation of infection resolution rates, treatment failure risk factors, adverse effects, and microbiological profiles.
  • Univariate logistic regression used to assess associations between treatment failure and various patient and infection characteristics.
  • 81.5% of patients achieved infection resolution without recurrence.
  • Acute kidney injury and acute liver injury were significantly associated with treatment failure.
  • Transient hypercalcemia risk was associated with calcium sulfate bead volume, but resolved in all cases without needing bead removal.

Cite This Study

Delcont et al. (2026) studied this question.

synapsesocial.com/papers/6a51dce1c18d7f28ca4ffd14https://doi.org/10.14444/8916
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibiotic-Infused Calcium Sulphate Beads in Spinal Infection: A Systematic Review of Small Series with Short-Term Follow-Up2026
  2. 2Use of Antibiotic-Eluting Calcium Sulfate in the Management of Post-surgical Spinal Infections and Spondylodiscitis: A Case Series2026
  3. 3Outcome of antibiotics bone beads in long bone chronic osteomyelitis2024
  4. 4Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review2026 · 6 citations
  5. 5Functional outcome of chronic osteomyelitis treated by sequestrectomy & saucerisation with antibiotic bead implantation2024