A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux

In two recent Nature studies, Yang et al. and Wang et al. independently revealed that human organic solute transporter alpha-beta (OSTαβ) is a lipid-tuned bile acid exporter with a previously unrecognized fold and a lateral-access transport pathway. These findings provide a structural framework for understanding basolateral bile acid efflux in the enterohepatic circulation and its relevance to metabolic signaling, cholestatic disease, and therapeutic targeting. 1 , 2