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July 11, 2026BMC Health Services ResearchOpen Access

Addressing real-world data gaps: estimating the uk population cost of crohn’s disease and ulcerative colitis using a flexible cost-of-illness model informed by the optimal patient journey and IBDUK patient survey 2023

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Authors

RMRachael MacDonaldNHNick HexBUBarbara Uzdzinska

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Overview

Cost-of-illness model estimates the economic burden of Crohn’s disease and ulcerative colitis in the UK, highlighting the need for better data.

Key Points

  • To estimate the population-level costs associated with Crohn's disease and ulcerative colitis in the UK using a flexible cost-of-illness model.
  • Developed a flexible cost-of-illness model informed by public data, the 2023 IBD UK survey, and published research.
  • The model considered factors like prevalence, diagnosis, management, complications, and mortality over 15 years.
  • Estimated direct NHS and indirect societal costs, including costs related to flare-ups and remission patterns.
  • Total annual direct healthcare cost for Crohn's disease and ulcerative colitis estimated at £3 billion.
  • Ongoing management accounts for 93% (£2.8 billion) of costs, with remission-related treatment being 84%.
  • Annual lost productivity cost is approximately £0.8 billion, primarily due to inability to work.

Cite This Study

MacDonald et al. (2026) studied this question.

synapsesocial.com/papers/6a51dce1c18d7f28ca4ffd89https://doi.org/10.1186/s12913-026-15060-6
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