Efficacy of ablative carbon dioxide laser in management of xanthelasma palpebrarum

Objectives:The objective of the study is to evaluate the efficacy and safety of ablative carbon dioxide (CO 2 ) laser in the treatment of xanthelasma palpebrarum.Methods: This interventional study included 90 patients aged 18-65 years with grade I-III xanthelasma.Patients with grade IV lesions and significant comorbidities were excluded.Baseline clinical and biochemical evaluation was performed.Lesions were treated with ablative CO 2 laser using standardized parameters (60-90 mJ energy, 210 Hz frequency).Patients were followed up monthly for 3 months.Efficacy was assessed using five-point scale score and patient satisfaction score.Results: Most patients were females (85.6%) and belonged to the 25-45-year age group (54.4%).Upper eyelid involvement was predominant (97.8%).Progressive improvement in lesion clearance was observed with > 75% clearance achieved in 56.7% patients at 3 months (p = 0.001).At the end of the study, 72.2% patients were very satisfied.Common adverse effects included erythema, edema, and scabbing.Hypopigmentation was the most frequent complication (65.6%), while recurrence occurred in 5.6% cases.Conclusion: Ablative CO 2 laser is a safe and effective treatment modality for xanthelasma palpebrarum, offering good cosmetic outcomes with high patient satisfaction and low recurrence rates.