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July 11, 2026Journal of Clinical MedicineOpen Access

MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson’s Disease

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Authors

SKSeda Nida KaraküçükMBMurat BaykaraCYCemile Buket Tugan Yıldız

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Overview

Retrospective study evaluates structural changes in the optic nerve in Parkinson's disease, suggesting imaging biomarker potential.

Key Points

  • The aim is to assess microstructural changes in the extraocular optic nerve of patients with idiopathic Parkinson's disease (IPD) using MRI.
  • Retrospective study of 74 participants, including 37 IPD patients and 37 controls.
  • Utilized T2-weighted MRI images and radiomic texture analysis on the extraocular optic nerve.
  • Statistical analyses included independent samples t-test, Mann–Whitney U test, and chi-square test.
  • Optic nerve sheath diameter (ONSD) was significantly greater in the IPD group (5.2 ± 0.8 mm vs. 3.2 ± 0.5 mm, p < 0.05).
  • Entropy values were significantly lower in IPD patients (p < 0.05).
  • GLRLM analysis showed lower short-run emphasis and higher long-run emphasis in IPD (p < 0.05), indicating structural changes.

Cite This Study

Karaküçük et al. (2026) studied this question.

synapsesocial.com/papers/6a51ddbfc18d7f28ca5000edhttps://doi.org/10.3390/jcm15145388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optic nerve diameter in early-stage idiopathic Parkinson's disease: A prospective observational study.2026
  2. 2Changes in Visual Evoked Potential and Optical Coherence Tomography in Parkinson’s Disease: A Systematic Review and Meta‐Analysis2025
  3. 3Structural changes in the retina as a potential biomarker in Parkinson's disease: an approach from optical coherence tomography2024 · 15 citations
  4. 4Influence of age on the thickness of retinal nerve fiber layer in patients with mild-to-moderate stages of Parkinson’s disease: Case series2024
  5. 5Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls2026