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July 11, 2026Clinical Transplantation and ResearchOpen Access

Prophylactic interventions for focal segmental glomerulosclerosis recurrence after kidney transplantation: a systematic review and network meta-analysis

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Authors

TPThemistoklis ParaskevasAKAnna KantaPPPanagiota Perdiki

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Overview

Systematic review evaluates interventions to prevent recurrent FSGS after kidney transplant, indicating inconclusive outcomes.

Key Points

  • The aim is to evaluate and compare the efficacy and safety of prophylactic interventions for preventing recurrent FSGS after kidney transplantation.
  • Conducted a systematic review and network meta-analysis of randomized and nonrandomized studies
  • Included patients with primary FSGS undergoing kidney transplantation
  • Search conducted on PubMed and Embase through July 2025.
  • Twenty-five studies evaluated six interventions, with no significant reduction in FSGS recurrence compared to control
  • Combination of rituximab and plasma exchange showed lower effect estimates, but not statistically significant
  • Adverse events reported infrequently, indicating limited safety concerns.

Cite This Study

Paraskevas et al. (2026) studied this question.

synapsesocial.com/papers/6a51ddbfc18d7f28ca50010chttps://doi.org/10.4285/ctr.25.0102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylactic treatment of FSGS recurrence in patients who relapsed in a previous kidney graft2024 · 6 citations
  2. 2Review of plasma exchange and rituximab for prevention of recurrent focal segmental glomerulosclerosis after a prior graft loss2024
  3. 3Recurrence of focal segmental glomerulosclerosis: An updated review of pathophysiology, biomarkers, and therapeutic strategies2026 · 2 citations
  4. 4Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study2024 · 15 citations
  5. 5Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation2024 · 2 citations