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July 11, 2026International Journal of Molecular SciencesOpen Access

Atopic Dermatitis Beyond the Skin Barrier: Precision Medicine Approaches to Immunological Profiling and Therapeutic Innovation

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Authors

VGVirgilios GalatisISIsabela SiloşiMAMohamed-Zakaria Assani

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Overview

Narrative review summarizes cytokine pathways and therapeutic innovations in atopic dermatitis, indicating potential for individualized treatment.

Key Points

  • The review aims to explore the immunopathogenesis of atopic dermatitis and the role of cytokine networks in its management.
  • Summarized evidence on immunopathogenesis and cytokine pathways in atopic dermatitis.
  • Discussed emerging biomarkers for disease severity and treatment responsiveness.
  • Reviewed advancements in therapies like biologics and JAK inhibitors under precision medicine.
  • Identified key cytokines (IL-4, IL-13, IL-31) driving inflammation and barrier dysfunction.
  • Highlighted diverse molecular endotypes that suggest targeted therapeutic strategies.
  • Emphasized need for ongoing biomarker development to enhance individualized treatment approaches.

Cite This Study

Galatis et al. (2026) studied this question.

synapsesocial.com/papers/6a51de38c18d7f28ca50035dhttps://doi.org/10.3390/ijms27146129
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