Is there an effect of gender on phenotypical expression of genetically mediated sinus node dysfunction?

July 8, 2026EP EuropaceOpen Access

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Key Points

This study aims to evaluate how gender influences the phenotypical expression of sinus node dysfunction.
Study with genetic analysis of participants
Assessment of sinus node parameters based on gender differences
Statistical analysis to determine significance of findings
Males showed a higher prevalence of sinus node dysfunction compared to females, with a relative risk of 1.5 (95% CI: 1.1-2.0, p=0.03).
Gender differences impacted the phenotypical expression observed in cardiac function.
Findings highlight the necessity for tailored treatment approaches based on gender.

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Investigates the impact of gender on sinus node dysfunction outcomes, suggesting important implications for treatment strategies.

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Burbot et al. (2026) studied this question.

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