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July 9, 2026JDDG Journal der Deutschen Dermatologischen GesellschaftOpen Access

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

Annabel H. Lechner Dennis D. Arnold Philipp P. Bosshard

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Key Points

The aim is to analyze clinical characteristics and antifungal susceptibility of Trichophyton indotineae in Switzerland.
Clinical data review of patients diagnosed at University Hospital Zurich (2014-2024)
Antifungal susceptibility testing and SQLE gene sequencing for 31 isolates
Analysis of SQLE data up to December 2025 to identify trends.
Marked increase in cases identified (35 total) in recent years.
SQLE mutations found in 20/31 (65%) isolates; 55/69 (80%) by 2025, with common mutations F397L, L393S, A448T.
Mutated strains required significantly longer treatment (11.5 weeks) compared to wild-type strains (3.5 weeks).

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Implication

Clinical analysis reveals increased Trichophyton indotineae cases in Switzerland with antifungal resistance, indicating treatment challenges.

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Cite This Study

Lechner et al. (2026) studied this question.

synapsesocial.com/papers/6a51e019c18d7f28ca500bcd https://doi.org/10.1111/ddg.70394

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