⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 9, 2026Human Reproduction

PAPSS2-mediated BMPR1A sulfation in stromal cells regulating endometrial decidualization via autophagy

Duo Zi Wanying Deng Xiaoli Zhang Yunfei Li Junzhi Liang Jia Hu Ruizhe Cao Wenhui Gao Na Zuo Hao Chen Da Li

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study investigates the role of PAPSS2-mediated sulfation in decidualization and its impact on recurrent implantation failure.
Analyzed transcriptomic datasets and conducted in vitro decidualization assays in human endometrial stromal cells (T-HESCs and hEnSCs).
Established an artificial decidualization mouse model and performed pharmacological modulation of BMP-SMAD signaling and autophagy.
Assessed effects of PAPSS2 knockdown and overexpression through RT-qPCR, Western blotting, immunoprecipitation, and immunofluorescence.
Sulfation levels in endometrial stromal cells were elevated in recurrent implantation failure patients.
PAPSS2 knockdown decreased BMPR1A sulfation and enhanced its binding affinity for BMP2, activating the SMAD1/5/9 pathway.
Activation of this pathway promoted autophagy, increasing decidualization and the receptivity of stromal cells to trophoblast invasion.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Examines how PAPSS2 influences decidualization in patients with recurrent implantation failure, suggesting new infertility treatments.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zi et al. (2026) studied this question.

synapsesocial.com/papers/6a51e084c18d7f28ca500d9b https://doi.org/10.1093/humrep/deag103

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Long noncoding RNA BMPR1B‐AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway2024 · 3 citations
2Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis2024 · 27 citations
3Decreased thrombospondin-1 impairs endometrial stromal decidualization in unexplained recurrent spontaneous abortion2024 · 3 citations
4Targeting the PRMT5-Nur77 methylation axis enhances endometrial decidualization capacity and female fertility in preclinical modelsRetrospective Study · 2026
5How Decidualization Dysregulation Reshapes the Nanomechanics of Endometrial Stromal CellsOriginal Research · 2026 · 2 citations