What question did this study set out to answer?

The study aims to explore whether baseline perfusion parameters affect clinical outcomes and modify the effect of endovascular therapy in isolated posterior cerebral artery occlusion.

July 11, 2026Stroke

Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke

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The study aims to explore whether baseline perfusion parameters affect clinical outcomes and modify the effect of endovascular therapy in isolated posterior cerebral artery occlusion.
Secondary analysis of the PLATO registry including consecutive adults with unilateral iPCAO and baseline perfusion imaging.
Employs multivariable mixed-effects regression and inverse probability of treatment weighting to assess relationships between perfusion parameters and outcomes.
Evaluates treatment-by-perfusion interactions for clinical outcomes.
Larger hypoperfusion volume correlated with lower odds of excellent outcomes (adjusted OR, 0.72 [95% CI, 0.58–0.89]).
Increasing core volume linked to less favorable modified Rankin Scale shifts (ratio of OR, 0.66 [95% CI, 0.48–0.90]; P interaction =0.009]) and higher mortality (ratio of OR, 1.82 [95% CI, 1.10–3.03]; P interaction =0.021).
Higher hypoperfusion volume associated with increased risk of symptomatic intracranial hemorrhage with EVT (ratio of OR, 10.15 [95% CI, 1.06–96.93]; P interaction =0.044).

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Implication

Randomized trial investigates perfusion imaging's role in outcomes of endovascular therapy for PCA occlusion, suggesting risks may vary.

Cite This Study

Diel et al. (2026) studied this question.

synapsesocial.com/papers/6a51e277c18d7f28ca501547 https://doi.org/10.1161/strokeaha.126.055949

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Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke

Key Points

Discussion

Implication

Cite This Study

Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke

Key Points

Discussion

Implication

Cite This Study

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