Polycystic ovary syndrome is associated with metabolic syndrome in approximately one-third to one-half of affected women and adolescent girls, likely linked by insulin resistance.
Metabolic syndrome is highly prevalent in women and adolescents with PCOS, necessitating early screening for impaired glucose tolerance and first-line therapy with lifestyle modification.
Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the metabolic syndrome. Early screening for impaired glucose tolerance, even in adolescents, is recommended. Lifestyle modification with increased physical activity and weight reduction remains first-line therapy. Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome.
Essah et al. (Thu,) conducted a review in Polycystic ovary syndrome (PCOS) and metabolic syndrome. Polycystic ovary syndrome is associated with metabolic syndrome in approximately one-third to one-half of affected women and adolescent girls, likely linked by insulin resistance.