December 12, 2016Neurogastroenterology & Motility
Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor‐alpha
Key result
Bilateral transcutaneous cervical vagal nerve stimulation increased cardiac vagal tone and reduced tumor necrosis factor-α at 24 hours compared to baseline in healthy subjects.
Why the study?
Does bilateral transcutaneous cervical vagal nerve stimulation modulate cardiac vagal tone and cytokines in healthy subjects?
Population
20 healthy subjects
Comparison
Bilateral transcutaneous cervical vagal nerve… vs Baseline (before-after comparison)
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
t-VNS effects on vagal tone and cytokines remain hypothesis-generating; leaves open therapeutic translation to cardiovascular patients.
Structured PICO
Does bilateral transcutaneous cervical vagal nerve stimulation modulate cardiac vagal tone and cytokines in healthy subjects?
P
Population
20 healthy subjects evaluated 24 hours after receiving bilateral transcutaneous cervical vagal nerve stimulation.
I
Intervention
Bilateral transcutaneous cervical vagal nerve stimulation (t-VNS)
C
Comparator
Baseline (before-after comparison)
O
Outcome
Parameters of autonomic tone and cytokinessurrogate
Transcutaneous cervical vagal nerve stimulation increases cardiac vagal tone and reduces TNF-alpha in healthy subjects at 24 hours, suggesting potential autonomic and anti-inflammatory effects.
Limitations
- Preliminary data
- Small sample size requiring larger controlled studies
- Requires larger controlled studies
Cite This Study
Brock et al. (2016) studied Healthy (n=20). Bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) vs. Baseline was evaluated on Parameters of autonomic tone and cytokines (cardiac vagal tone and tumor necrosis factor-α). Bilateral transcutaneous cervical vagal nerve stimulation increased cardiac vagal tone and reduced tumor necrosis factor-α at 24 hours compared to baseline in healthy subjects.