June 22, 2009Echocardiography118 citationsOpen Access
Mitral Regurgitation Associated with Mitral Annular Dilation in Patients with Lone Atrial Fibrillation: An Echocardiographic Study
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Key Result
Lone AF patients with functional mitral regurgitation had greater mitral valve annular and left atrial areas compared to controls without MR, despite similar LV volumes and ejection fraction.
Study Design
Type
Case-Control (n=22)
Structured PICO
Is functional mitral regurgitation in patients with lone atrial fibrillation associated with mitral annular and left atrial dilation?
P
Population
22 lone atrial fibrillation patients without left ventricular dysfunction or dilatation, comprising 12 with functional mitral regurgitation and 10 controls without.
E
Exposure
Lone atrial fibrillation with functional mitral regurgitation
C
Comparator
Lone atrial fibrillation without mitral regurgitation
O
Outcome
Mitral valve annular area and left atrial areasurrogate
In patients with lone atrial fibrillation, functional mitral regurgitation is associated with left atrial and mitral annular dilation rather than left ventricular dysfunction.
Abstract
BACKGROUND: Whether and how lone atrial fibrillation (AF) is associated with functional mitral regurgitation (MR) remain unclear. METHOD: We studied 12 lone AF patients without left ventricular (LV) dysfunction and/or dilatation, who underwent mitral valve annuloplasty for functional mitral regurgitation (MR). Ten lone AF patients without MR served as controls. RESULTS: Lone AF Patients with MR had a greater mitral valve annular area and left atrial area than those without MR. There were no differences in LV volumes or LV ejection fraction. CONCLUSIONS: Therefore, we concluded that left atrial dilation and corresponding mitral annular dilation may cause MR in lone AF patients without LV dysfunction and/or dilatation.