Key result
Atrial functional mitral regurgitation pathogenesis involves both LA remodeling and LV structural and functional abnormalities.
Why the study?
Emerging evidence suggests atrial functional mitral regurgitation is not solely caused by left atrial remodeling from atrial fibrillation, but also involves structural and functional left ventricular abnormalities.
The pathogenesis of atrial functional mitral regurgitation extends beyond left atrial remodeling to include left ventricular structural and functional abnormalities.
May warrant LV evaluation in AF-MR; leaves open optimal therapeutic targets.
Recent studies lend credibility to the notion that lone atrial fibrillation (AF) can cause functional mitral regurgitation (MR), commonly referred to as atrial functional MR (AF-MR). The conventional view holds that left atrial enlargement associated with AF causes annular dilatation which gradually moves the mitral valve leaflets apart resulting in inadequate coaptation and regurgitation. Recent findings, however, suggest that AF-MR is not solely related to left atrial remodeling, but that important structural and functional abnormalities of the left ventricle also play a role in its pathogenesis.
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Jeffrey J. Silbiger (2019) conducted a review in Atrial functional mitral regurgitation (AF-MR). Atrial fibrillation was evaluated. Atrial functional mitral regurgitation pathogenesis involves not only left atrial remodeling but also important structural and functional abnormalities of the left ventricle.
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