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July 12, 2026BMC Infectious DiseasesOpen Access

Burden of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma in Africa: a systematic review and meta-analysis

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The aim was to characterize the burden of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma across Africa through a systematic review and meta-analysis.
Conducted a systematic review and meta-analysis of studies reporting EBV prevalence in NPC, GC, and BL from 2000 to March 2025.
Performed subgroup analyses by region and detection method, and assessed study quality using the Joanna Briggs Institute checklist.
Estimated pooled prevalence using a random-effects model and analyzed publication bias with Begg's and Egger's tests.
Pooled EBV prevalence was 86.8% for Burkitt lymphoma, 66.0% for nasopharyngeal carcinoma, and 35.4% for gastric cancer, showing significant heterogeneity (I² >95%, p < 0.001).
Nasopharyngeal carcinoma had the highest prevalence in East Africa at 81.8% and the lowest in North Africa at 50.0%.
Detection method EBER-ISH showed a higher prevalence of NPC at 80.4% compared to DNA PCR at 60.3%.

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Implication

Systematic review estimates prevalence of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma, highlighting regional differences among African populations.

Cite This Study

Sebsibe et al. (2026) studied this question.

synapsesocial.com/papers/6a532e014f7abc118adeca15 https://doi.org/10.1186/s12879-026-13980-6

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Implication

Systematic review estimates prevalence of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma, highlighting regional differences among African populations.

Burden of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma in Africa: a systematic review and meta-analysis

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Implication

Cite This Study

Burden of Epstein-Barr virus in gastric cancer, nasopharyngeal carcinoma, and Burkitt lymphoma in Africa: a systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study