Introductory guide demonstrates scanning ion conductance microscopy for investigating live-cell dynamics, suggesting practical applications.
High-resolution minimally invasive imaging of live cells is essential for investigating cellular morphology and its dynamic changes. Scanning ion conductance microscopy (SICM) offers a unique combination of precise topographic imaging down to the nanoscale with experimental conditions that preserve realistic live-cell behavior. This practical guide walks readers through critical aspects including instrumentation, probe characterization, cell preparation and morphometric data extraction and presentation, equipping them to implement SICM with confidence and begin exploring live-cell structure and dynamics.
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Papa et al. (2026) studied this question.
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