What question did this study set out to answer?

This review aims to evaluate and grade the evidence linking hyperhomocysteinemia to various health outcomes.

Hyperhomocysteinemia, a risk factor for various health conditions: an umbrella review of systematic reviews with meta-analysis

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Umbrella review finds hyperhomocysteinemia linked to numerous health issues, suggesting a need for preventive measures.

This review aims to evaluate and grade the evidence linking hyperhomocysteinemia to various health outcomes.
Systematic review and meta-analysis of observational studies
Searched databases: Medline, Embase, and Web of Science
Quality assessed using AMSTAR-2 and evidence graded using GRADE
83% of evaluated outcomes showed significant associations with hyperhomocysteinemia
High-certainty evidence linked hyperhomocysteinemia to risks of stroke, fractures, and chronic kidney disease
Moderate-certainty evidence connected it to dementia and several cardiovascular outcomes.

Castagna et al. (2026) studied this question.

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