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July 9, 2026Protein & CellOpen Access

Designed nanoparticles enable multivalent display of influenza HA to drive rapid, potent, durable, and cross-reactive antibody responses

Pi Liu Y. Xi Jiali Deng Shiqiang Luo T Liu Chengying Ding Qianhui Zhu He Lp Mingkai Li Nan Wang Yong Liu Xiangxi Wang

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Key Points

This research aims to explore how designed nanoparticles can enhance antibody responses to influenza HA.
Created designed nanoparticles displaying multivalent influenza hemagglutinin (HA) for immune activation.
Assessed antibody responses in a relevant biological system to evaluate efficacy.
Analyzed durability and cross-reactivity of antibody responses generated by the nanoparticle intervention.
Demonstrated rapid antibody response development post-intervention.
Elicited potent and durable antibody levels, with significant cross-reactivity against various influenza strains.

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Implication

Shows designed nanoparticles drive robust antibody responses against influenza, indicating potential vaccine advancements.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a5330a44f7abc118aded458 https://doi.org/10.1093/procel/pwag046

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