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July 12, 2026Science AdvancesOpen Access

Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells

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Authors

ACAlma‐Martina CepikaLALaura AmayaCWColin Waichler

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Overview

Multiomic profiling uncovers transcriptional regulators in human Tr1 cells, suggesting therapeutic applications.

Key Points

  • The study aims to identify key regulators and the transcriptional landscape involved in the differentiation of human Tr1 cells.
  • Conducted multiomic profiling of human antigen-induced Tr1 cells.
  • Utilized CRISPR-based functional genomics to identify essential transcription factors IRF4, BATF, and MAF.
  • Derived a Tr1 transcriptional signature for detecting Tr1 cells in single-cell datasets from patients.
  • Identified IRF4, BATF, and MAF as crucial transcription factors in Tr1 differentiation.
  • Established a Tr1 transcriptional signature that detects Tr1 phenotype in diverse patient datasets.
  • Confirmed the signature identifies authentic Tr1 cells induced in vivo within a murine solid tumor model.

Cite This Study

Cepika et al. (2026) studied this question.

synapsesocial.com/papers/6a5331ce4f7abc118adeda33https://doi.org/10.1126/sciadv.aec6358
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