The efficacy-invasiveness trade-off: a retrospective cohort comparison of surgical operation and endobronchial valves for refractory lung bullae disease
Retrospective cohort comparison evaluates outcomes of surgical operations versus endobronchial valves for lung bullae, suggesting individualized treatment plans.
Key Points
This study aims to compare the long-term efficacy and safety of surgical operations versus endobronchial valves for refractory lung bullae.
Retrospective cohort analysis of 673 patients with refractory bullae disease from two Chinese centers.
Propensity score matching was applied to control for confounding factors.
Outcomes analyzed include perioperative metrics, 1-year efficacy, and long-term recurrence-free survival.
SO led to significant improvements in lung function (adjusted mean FEV1%: -9.71%, p < 0.001) and exercise capacity (adjusted mean 6MWD: -53.04 m, p < 0.001).
After matching, SO had higher 2-year recurrence-free survival rate (86.5%) compared to EBV (70.0%), with HR for EBV at 2.48 (p < 0.001).
EBV resulted in lower complication rates (OR = 0.33) but was associated with higher long-term costs (mean increase ¥104,502).