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July 12, 2026Critical Reviews in Toxicology

Setting occupational exposure limits (OELs) for carcinogens: a focus on benzene

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Authors

MPMaria de Fatima M. PedrozoMPMônica Maria Bastos Paoliello

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Overview

Narrative review compares two approaches to establish benzene's occupational exposure limits, indicating implications for worker health.

Key Points

  • This review aims to evaluate and compare methods for setting Occupational Exposure Limits for benzene as a carcinogen.
  • Narrative review of two approaches in establishing OELs for benzene.
  • Comparison of mode of action-based approach and quantitative genotoxicity analysis.
  • Assessment of current OELs proposed by various regulatory bodies across Europe.
  • Proposed OELs for benzene range between 0.021 and 0.25 ppm depending on the approach used.
  • Current evidence indicates workplace benzene concentrations exceeding 0.3 ppm fail to protect worker health.
  • Recommendations include extending cohort follow-up and robust quantitative genotoxicity assays.

Cite This Study

Pedrozo et al. (2026) studied this question.

synapsesocial.com/papers/6a5331ce4f7abc118adedb2bhttps://doi.org/10.1080/10408444.2026.2669526
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