Randomized trial demonstrates effective deoxyamination of alcohols with broad substrate scope, suggesting new pharmaceutical applications.
Optically active nitrogen-bearing molecules are central to drug discovery, which has driven the development of efficient, stereocontrolled C(sp 3 )–N bond-forming methods. Herein we report a SuFEx-enabled platform that directly couples diverse alcohols and free N-nucleophiles via deoxygenative C(sp 3 )–N(sp 3 /sp 2 ) bond formation with high stereospecificity without elimination. Using an inexpensive lithium triflate salt to suppress competitive deoxyfluorination, this method enables facile deoxyamination with broad substrate scope, N-heterocycle synthesis, late-stage functionalization, and stereodivergent synthesis of pharmaceuticals.
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Odoh et al. (2026) studied this question.
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