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July 12, 2026Experimental and Molecular PathologyOpen Access

METTL13 at the interface of translational control, protein methylation, and disease biology

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Authors

JHJiejie HeYYYongli YangYLYan Li

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Overview

Narrative review summarizes METTL13's functions in translation control and disease contexts, indicating regulatory complexity.

Key Points

  • This review explores the structural and functional roles of METTL13 in translation control and its implications in various diseases.
  • Summarized structural features and molecular mechanisms of METTL13
  • Reviewed its roles in malignancies and non-malignant diseases
  • Integrated clinical translation evidence and regulatory network of METTL13
  • METTL13 enhances eEF1A GTPase activity, promoting protein production.
  • Associations found between METTL13, eEF1A-K55 methylation, and tumor progression in various cancer settings.
  • Context-dependent roles of METTL13 noted, including protective effects in ischemic heart failure and hereditary deafness.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a5332484f7abc118adedd38https://doi.org/10.1016/j.yexmp.2026.105064
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