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July 12, 2026CureusOpen Access

Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials

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Authors

AAAhmed M AlhussainSASarah Turki M. AlbusayysMAMohammed A Alfhadi

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Implication

Systematic review shows that polynucleotide-based therapies improve outcomes in skin rejuvenation and wound healing.

Key Points

  • This review aims to assess the effectiveness of polynucleotides and polydeoxyribonucleotides in skin rejuvenation, scar prevention, and wound healing through randomized trials.
  • Conducted a systematic review of randomized clinical trials from PubMed, Embase, and CENTRAL.
  • Included seven randomized trials involving 183 participants focusing on skin rejuvenation, scar prevention, and wound healing.
  • Evaluated the effectiveness of PN and PDRN therapies on various outcomes such as wrinkle reduction and healing time.
  • PN and PDRN therapies significantly improved wrinkle-related scores and scar quality metrics.
  • In wound-healing settings, PDRN accelerated re-epithelialization and reduced healing time compared to controls.
  • No serious adverse events were reported, though the evidence was limited by small sample sizes and varied outcomes.

Cite This Study

Alhussain et al. (2026) studied this question.

synapsesocial.com/papers/6a5332f94f7abc118adedec5https://doi.org/10.7759/cureus.112403
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