Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 12, 2026Clinical & Experimental Immunology

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum

View Full Paper
Ask AI
Bookmark
Share

Authors

HLHeather LoughnaneTrinity CollegeSBShrikanth Chomanahalli BasavarajappaTrinity College DublinADAnna DominikTrinity College

Discussion

Loading...

Member takes

Overview

Randomized trial investigates the role of Nrf2 activation in reducing inflammation in coeliac disease, suggesting therapeutic potential.

Key Points

  • This research aims to explore the role of Nrf2 in managing redox imbalance and its connection to inflammation in coeliac disease.
  • Utilized single cell transcriptomics to analyze oxidative stress and Nrf2 activation in duodenal biopsies from coeliac disease patients.
  • Assessed gene expression of oxidative stress markers across various cell subsets.
  • Evaluated the impact of Nrf2 pharmacological activation on inflammatory gene expression induced by gliadin.
  • Oxidative stress markers were significantly increased across multiple cell types in the coeliac mucosa.
  • Nrf2 activation markers were decreased in activated CD4+ T cells and intraepithelial T lymphocytes.
  • Pharmacological activation of Nrf2 reduced gliadin-induced IFNG expression in duodenal biopsies.

Cite This Study

Loughnane et al. (2026) studied this question.

synapsesocial.com/papers/6a5334194f7abc118adee1echttps://doi.org/10.1093/cei/uxag042
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1UCell: Robust and scalable single-cell gene signature scoring2021 · 1,166 citations
  2. 2Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier2023 · 116 citations