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This review aims to summarize the mechanisms by which Epstein–Barr virus influences apoptosis regulation in epithelial cancers.

July 12, 2026BiologyOpen Access

Epstein–Barr Virus-Mediated Apoptosis Evasion in Epithelial Malignancies: Molecular Mechanisms and Therapeutic Implications

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Review highlights how Epstein–Barr virus evades apoptosis in epithelial malignancies, suggesting therapeutic strategies.

This review aims to summarize the mechanisms by which Epstein–Barr virus influences apoptosis regulation in epithelial cancers.
Analyzed the relationship between EBV infection and apoptosis in epithelial malignancies.
Reviewed evidence on EBV genome organization and infection programs.
Discussed how EBV proteins modulate apoptotic pathways.
EBV promotes apoptosis resistance through effects on mitochondrial pathways and death receptor-mediated cell death.
Viral proteins alter key apoptotic regulators, including p53 and Bcl-2 family members.

Blanco et al. (2026) studied this question.

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