Why the study?
Does early electrocardiography predict mortality and progressive cardiac lesions in patients with asymptomatic Trypanosoma cruzi infection?
Population
1017 residents of a rural Brazilian community, 42% initially seropositive for Trypanosoma cruzi infection.
Design
Cohort
Follow-up
7 years
Key result
In a 7-year follow-up of 1,017 residents (42% seropositive), Trypanosoma cruzi infection led to progressive cardiac lesions and high mortality among adults with ventricular conduction defects.
Authors
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Suggests early cardiac evaluation post-infection in endemic areas; hypothesis-generating for preventive interventions.
Cohort (n=1,017)
No
Does early electrocardiography predict mortality and progressive cardiac lesions in patients with asymptomatic Trypanosoma cruzi infection?
Early electrocardiography in asymptomatic Chagas' disease patients can identify those at high risk for progressive cardiac lesions and mortality.
Maguire et al. (1987) conducted a cohort in Chagas' disease (n=1,017). Trypanosoma cruzi infection vs. Seronegative residents was evaluated on Development of cardiac lesions (ventricular conduction defects) and mortality. In a 7-year follow-up of 1,017 residents (42% seropositive), Trypanosoma cruzi infection led to progressive cardiac lesions and high mortality among adults with ventricular conduction defects.