Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi –Seropositive Former Blood Donors
Key result
Asymptomatic Trypanosoma cruzi-seropositive blood donors developed Chagas cardiomyopathy at a rate of 24% over ~11 years compared to 5% in seronegative controls.
Why the study?
Does Trypanosoma cruzi seropositivity increase the incidence of Chagas cardiomyopathy in initially asymptomatic blood donors?
Population
987 initially healthy blood donors from Brazil.
Comparison
Trypanosoma cruzi seropositivity (exposure) vs Trypanosoma cruzi seronegativity
Design
Cohort, ECG and echocardiogram results classified by blinded core…
Follow-up
mean 10.5 years for seropositives and 11.1 years for…
Authors
Discussion
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Implication
Supports vigilance for Chagas cardiomyopathy in asymptomatic seropositives; leaves open optimal monitoring intervals and risk stratification.
Study Design
Type
Cohort (n=987)
Blinding
Blinded outcome assessment
Multicenter
Yes
Structured PICO
Does Trypanosoma cruzi seropositivity increase the incidence of Chagas cardiomyopathy in initially asymptomatic blood donors?
P
Population
987 initially healthy blood donors (499 T cruzi-seropositive and 488 matched seronegative) followed for approximately 11 years to assess the incidence of Chagas cardiomyopathy.
E
Exposure
Trypanosoma cruzi seropositivity (exposure)
C
Comparator
Trypanosoma cruzi seronegativity
O
Outcome
Incidence of Chagas cardiomyopathy, adjudicated by a blinded panel of 3 cardiologists based on ECG and echocardiogram resultshard clinical
Main Result
Effect estimate: Incidence difference 1.85 per 100 person-years
Absolute Event Rate: 24% vs 5%
Asymptomatic T. cruzi-seropositive blood donors have a substantial 10-year incidence of developing Chagas cardiomyopathy, although the disease is typically mild at diagnosis.
Cite This Study
Sabino et al. (2013) conducted a cohort in Chagas cardiomyopathy (n=987). Trypanosoma cruzi seropositivity vs. Trypanosoma cruzi seronegativity was evaluated on Definite Chagas cardiomyopathy (Incidence difference 1.85 per 100 person-years). Asymptomatic Trypanosoma cruzi-seropositive blood donors developed Chagas cardiomyopathy at a rate of 24% over ~11 years compared to 5% in seronegative controls.